APC Anti-Mouse CD115/CSF-1R Antibody[AFS98]
Product Sizes
25 ug
£115.00
E-AB-F1107UE-25UG
100 ug
£226.00
E-AB-F1107UE-100UG
About this Product
- SKU:
- E-AB-F1107UE
- Additional Names:
- CD115;CSF-1 receptor (EC:2.7.10.1);CSF-1-R;CSF-1R;Csf1r;Csfmr;Fms;M-CSF-R;Macrophage colony-stimulating factor 1 receptor;Proto-oncogene c-Fms
- Application:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- AFS98
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Concentration:
- 0.2 mg/ml
- Extra Details:
- CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
- Host:
- Rat
- Immunogen:
- CD115/CSF-1R
- Isotype:
- IgG2a, kappa
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:csf_1r_antibody[afs98]-e_ab_f1107ue
