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Antibodies

Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98], Functional Grade

Product Sizes
100 ug
£89.00
E-AB-F11070-100UG
1 mg
£171.00
E-AB-F11070-1MG
5 mg
£490.00
E-AB-F11070-5MG
25 mg
£1515.00
E-AB-F11070-25MG
50 mg
£2247.00
E-AB-F11070-50MG
100 mg
£3211.00
E-AB-F11070-100MG
About this Product
SKU:
E-AB-F11070
Additional Names:
CD115,CSF-1 receptor (EC:2.7.10.1),CSF-1-R,CSF-1R,Csf1r,Csfmr,Fms,M-CSF-R,Macrophage colony-stimulating factor 1 receptor,Proto-oncogene c-Fms
Application:
Block/Inhibit/Neutralise, Depletion, Flow Cytometry
Buffer:
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
translate.label.attr.clone:
AFS98
Clonality:
Monoclonal
Concentration:
>= 1 mg/ml
Extra Details:
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
Host:
Rat
Immunogen:
Recombinant Mouse CD115 protein
Isotype:
IgG2a, kappa
Purity:
>98%
Purification:
protein a/g purified
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
Mouse peritoneal macrophages were stained with 0.2 ug Purified Anti-Mouse CD115 Antibody[AFS98], Functional Grade(Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control(Left), followed by APC-conjugated Goat Anti-Rat IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL-2 gene were stained with 0.2 ug AF/LE Purified Anti-Human IL-2 Antibody[MQ1-17H12] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse IL-2 gene were stained with 0.2 ug AF/LE Purified Anti-Mouse IL-2 Antibody[JES6-5H4] (Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor®647-conjugated Goat Anti-Rat IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL-2 gene were stained with 0.2 ug Purified Anti-Human IL-2 Antibody[MQ1-17H12] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse IL-2 gene were stained with 0.2 ug Purified Anti-Mouse IL-2 Antibody[JES6-5H4] (Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor®647-conjugated Goat Anti-Rat IgG Secondary Antibody.