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Antibodies

Purified Anti-Mouse CD272/BTLA Antibody[PK18.6]

Product Sizes
25 ug
£66.00
E-AB-F1024A-25UG
100 ug
£89.00
E-AB-F1024A-100UG
1 mg
£165.00
E-AB-F1024A-1MG
5 mg
£467.00
E-AB-F1024A-5MG
25 mg
£1438.00
E-AB-F1024A-25MG
50 mg
£2132.00
E-AB-F1024A-50MG
100 mg
£2980.00
E-AB-F1024A-100MG
About this Product
SKU:
E-AB-F1024A
Additional Names:
A630002H;A630002H24;B- and T-lymphocyte attenuator;B- and T-lymphocyte-associated protein;CD272;Btla;HVEM; HVEA; TR2; TNFRSF14; ATAR
Application:
Flow Cytometry
Buffer:
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
translate.label.attr.clone:
PK18.6
Clonality:
Monoclonal
Concentration:
>= 1 mg/ml
Extra Details:
B and T lymphocyte attenuator (BTLA) is an Ig superfamily coinhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand Herpes Virus Entry Mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significant up-regulated expression of BTLA compared with effector and naive T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It has been reported that BTLA may regulate T cell function through binding to B7-H4.
Host:
Rat
Immunogen:
CD272
Isotype:
IgG1, kappa
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
  • Manufacturer's Data Sheet:4mbjrH
C57BL/6 Mouse bone marrow cells were stained with 0.2 ug AF/LE Purified Anti-Mouse Ly-6G/Ly-6C (Gr-1) Antibody[RB6-8C5] (Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
C57BL/6 Mouse bone marrow cells were stained with 0.2 ug Purified Anti-Mouse Ly-6G/Ly-6C (Gr-1) Antibody[RB6-8C5](Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control(Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
C57BL/6 Mouse bone marrow cells were stained with 0.2 ug AF/LE Purified Anti-Mouse Ly6C Antibody[Monts 1] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
C57BL/6 Mouse bone marrow cells were stained with 0.2 ug AF/LE Purified Anti-Mouse Ly-6G/Ly-6C (Gr-1) Antibody[RB6-8C5] (Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug AF/LE Purified Anti-Mouse TCRB Beta Antibody[H57-597] (Right) and 0.2 ug Armenian Hamster IgG, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti- Armenian Hamster IgG Secondary Antibody, then anti-Mouse CD3 PE-conjugated Monoclonal Antibody.