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Antibodies

Purified Anti-Mouse CD272/BTLA Antibody[PK18.6], Functional Grade

Product Sizes
100 ug
£89.00
E-AB-F10240-100UG
1 mg
£171.00
E-AB-F10240-1MG
5 mg
£490.00
E-AB-F10240-5MG
25 mg
£1515.00
E-AB-F10240-25MG
50 mg
£2247.00
E-AB-F10240-50MG
100 mg
£3211.00
E-AB-F10240-100MG
About this Product
SKU:
E-AB-F10240
Additional Names:
A630002H,A630002H24,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,CD272,Btla,HVEM, HVEA, TR2, TNFRSF14, ATAR
Application:
Flow Cytometry, Stimulation
Buffer:
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
translate.label.attr.clone:
PK18.6
Clonality:
Monoclonal
Concentration:
>= 1 mg/ml
Extra Details:
B and T lymphocyte attenuator (BTLA) is an Ig superfamily coinhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand Herpes Virus Entry Mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significant up-regulated expression of BTLA compared with effector and naive T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It has been reported that BTLA may regulate T cell function through binding to B7-H4. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
Host:
Rat
Immunogen:
Recombinant Mouse CD272 protein
Isotype:
IgG1, kappa
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
C57/BL6 Mouse splenocytes were stained with 0.2 ug Purified Anti-Mouse CD272 Antibody[PK18.6](Right) and 0.2 ug Rat IgG1, K Kappa Isotype Control (Left), followed by APC-conjugated Goat Anti-Rat IgG Secondary Antibody, then anti-Mouse B220 PE-conjugated Monoclonal Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug Purified Anti-Mouse CD183/CXCR3 Antibody[CXCR3-173] (Right) and 0.2 ug Armenian Hamster IgG, K Kappa Isotype Control (Left), followed by PE-conjugated Goat Anti-Armenian Hamster IgG Secondary Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Human CD123 Antibody[6H6] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by APC-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD45RO FITC-conjugated Monoclonal Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Human CD11c Antibody[BU15] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD56 PE-conjugated Monoclonal Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug AF/LE Purified Anti-Mouse CD183/CXCR3 Antibody[CXCR3-173] (Right) and 0.2 ug Armenian Hamster IgG, K Kappa Isotype Control (Left), followed by PE-conjugated Goat Anti-Armenian Hamster IgG Secondary Antibody.