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Antibodies

Purified Rat IgG1, K Kappa Isotype Control[HRPN]

Product Sizes
25 ug
£66.00
E-AB-F09823A-25UG
100 ug
£89.00
E-AB-F09823A-100UG
1 mg
£165.00
E-AB-F09823A-1MG
5 mg
£467.00
E-AB-F09823A-5MG
25 mg
£1438.00
E-AB-F09823A-25MG
50 mg
£2132.00
E-AB-F09823A-50MG
100 mg
£2980.00
E-AB-F09823A-100MG
About this Product
SKU:
E-AB-F09823A
Application:
Flow Cytometry
Buffer:
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
translate.label.attr.clone:
HRPN
Clonality:
Monoclonal
Concentration:
>= 1 mg/ml
Extra Details:
CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naive T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.
Host:
Rat
Isotype:
IgG1, kappa
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Isotype Controls
  • Manufacturer's Data Sheet:Ta5ivL
Human peripheral blood lymphocytes cell were stained with 0.2 ug Purified Anti-Human CD5 Antibody[HISM2] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD3 PE-conjugated Monoclonal Antibody.
KG1 cell were stained with 0.2 ug Purified Anti-Human CD34 Antibody[4H11] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by FITC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Human CD11a Antibody[HI111] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by FITC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood lymphocytes cell were stained with 0.2 ug Purified Anti-Human CD5 Antibody[HISM2] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD3 PE-conjugated Monoclonal Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug AF/LE Purified Anti-Human CD11a Antibody[HI111] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by FITC-conjugated Goat Anti-Mouse IgG Secondary Antibody.