NGEF Polyclonal Antibody
Product Sizes
60 ul
£217.00
E-AB-91558-60UL
120 ul
£317.00
E-AB-91558-120UL
200 ul
£492.00
E-AB-91558-200UL
About this Product
- SKU:
- E-AB-91558
- Additional Names:
- ARHGEF27,EPHEXIN,NGEF,ephexin-1
- Application:
- Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Acts as a guanine nucleotide exchange factor (GEF which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity.
- Host:
- Rabbit
- Immunogen:
- Recombinant fusion protein of human NGEF
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-ngef_polyclonal_antibody-e_ab_91558
