Recombinant Glucocorticoid Receptor Monoclonal Antibody
Product Sizes
50 ul
£198.00
E-AB-81561-50UL
100 ul
£291.00
E-AB-81561-100UL
About this Product
- SKU:
- E-AB-81561
- Additional Names:
- GCCR;GCR;GCRST;GR;GRL
- Application:
- Immunofluorescence, Western Blot
- Buffer:
- 50mm tris-glycine
- translate.label.attr.clone:
- R04-8C8
- Clonality:
- Monoclonal
- Concentration:
- 300 ug/ml
- Extra Details:
- Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546).
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of mouse Glucocorticoid Receptor
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:p-recombinant_glucocorticoid_receptor_monoclonal_antibody-e_ab_81561
