Recombinant Axin 2 Monoclonal Antibody
Product Sizes
50 ul
£198.00
E-AB-81534-50UL
100 ul
£291.00
E-AB-81534-100UL
About this Product
- SKU:
- E-AB-81534
- Additional Names:
- AXIL;AXIN2;ODCRCS;axin-2
- Application:
- Western Blot
- Buffer:
- 50mm tris-glycine
- translate.label.attr.clone:
- R06-3A8
- Clonality:
- Monoclonal
- Concentration:
- 300 ug/ml
- Extra Details:
- The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human Axin 2
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:p-recombinant_axin_2_monoclonal_antibody-e_ab_81534
