JNK1/2/3 Polyclonal Antibody
Product Sizes
60 ul
£198.00
E-AB-70345-60UL
120 ul
£291.00
E-AB-70345-120UL
200 ul
£430.00
E-AB-70345-200UL
About this Product
- SKU:
- E-AB-70345
- Additional Names:
- JNK-46,JNK1,JNK2,MAP kinase 8,MAPK 8,MAPK8,MAPK9,Mi,Mitogen-activated protein kinase 8,PRKM8,PRKM9,SAPK1,SAPK1A,SAPK1C,SAPK1c,Stress-activated protein kinase 1c,Stress-activated protein kinase JNK1,c-Jun N-terminal kinase 1
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 400 ug/ml
- Extra Details:
- c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield ten isoforms through alternative mRNA splicing, including JNK1A Alpha1,JNK1B Beta1, JNK2A Alpha1, JNK2B Beta1 and JNK3A Alpha1, which represent the p46 isoforms, and JNK1A Alpha2, JNK1B Beta2, JNK2A Alpha2, JNK2B Beta2 and JNK3B Beta2, which represent the p54 isoforms. JNKs coordinate cell responses to stress and influence regulation of cell growth and ransformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38.
- Host:
- Rabbit
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to human JNK1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:3_polyclonal_antibody-e_ab_70345
