PD-1/CD279 Polyclonal Antibody
Product Sizes
60 ul
£198.00
E-AB-70311-60UL
120 ul
£291.00
E-AB-70311-120UL
200 ul
£430.00
E-AB-70311-200UL
About this Product
- SKU:
- E-AB-70311
- Additional Names:
- CD279;CD279 antigen;PD 1;PD-1;PD1;PDCD 1;PDCD1;Programmed cell death 1;Programmed cell death 1 protein;Programmed cell death protein 1;Protein PD 1;Protein PD-1;SLEB2;Systemic lupus erythematosus susceptibility 2;hPD 1;hPD l;hPD-1;hSLE1
- Application:
- Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 0.75 mg/ml
- Extra Details:
- Programmed cell death 1 (PD-1,also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain,a stalk,a transmembrane domain,and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) . PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines . Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation,cytokine production,and cytolytic function . It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity . The calculated molecular weight of PD-1 is 32 kDa. It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE .
- Host:
- Rabbit
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse PD-1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:cd279_polyclonal_antibody-e_ab_70311
