MGMT Polyclonal Antibody
Product Sizes
60 ul
£198.00
E-AB-70262-60UL
120 ul
£291.00
E-AB-70262-120UL
200 ul
£430.00
E-AB-70262-200UL
About this Product
- SKU:
- E-AB-70262
- Additional Names:
- 6 O methylguanine DNA methyltransferase,6-O-methylguanine-DNA methyltransferase,AGT,AI267024,Agat,EC 2.1.1.63,MGC10702,Methylated DNA protein cysteine methyltransferase,Methylated-DNA--protein-cysteine methyltransferase,Methylguanine DNA methyltransferase
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 260 ug/ml
- Extra Details:
- MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Mouse MGMT
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-mgmt_polyclonal_antibody-e_ab_70262
