NPHS1 Polyclonal Antibody
Product Sizes
60 ul
£198.00
E-AB-70211-60UL
120 ul
£291.00
E-AB-70211-120UL
200 ul
£430.00
E-AB-70211-200UL
About this Product
- SKU:
- E-AB-70211
- Additional Names:
- CNF,Finnish type (nephrin),NPHN,NPHS 1,Nephrin,Nephrosis 1,Nephrosis 1 congenital Finnish type,Nphs1,Renal glomerulus specific cell adhesion receptor,Renal glomerulus-specific cell adhesion receptor,congenital
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1.3 mg/ml
- Extra Details:
- This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in transfected COS-7 cell lysates.
- Host:
- Rabbit
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse Nephrin
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-nphs1_polyclonal_antibody-e_ab_70211
