INPP5D Polyclonal Antibody
Product Sizes
60 ul
£198.00
E-AB-70200-60UL
120 ul
£291.00
E-AB-70200-120UL
200 ul
£430.00
E-AB-70200-200UL
About this Product
- SKU:
- E-AB-70200
- Additional Names:
- 4,5-trisphosphate 5-phosphatase 1,INPP5D,Inositol polyphosphate 5 phosphatase,Inositol polyphosphate 5 phosphatase 145kDa,Inositol polyphosphate 5 phosphatase of 145kDa,Inositol polyphosphate-5-phosphatase of 145 kDa,MGC104855,MGC142140,MGC142142,hp51CN,p
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 430 ug/ml
- Extra Details:
- This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.
- Host:
- Rabbit
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse SHIP1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-inpp5d_polyclonal_antibody-e_ab_70200
