p21 Polyclonal Antibody
Product Sizes
60 ul
£198.00
E-AB-70068-60UL
120 ul
£291.00
E-AB-70068-120UL
200 ul
£430.00
E-AB-70068-200UL
About this Product
- SKU:
- E-AB-70068
- Additional Names:
- CAP20,CDK-interacting protein 1,CDKI,CDKN1,CDN1A,CIP1,Cdkn1a,Cip1),Cyclin Dependent Kinase Inhibitor 1A,Cyclin-dependent kinase inhibitor 1,Cyclin-dependent kinase inhibitor 1A (P21),Cyclin-dependent kinase inhibitor 1A (p21,DNA Synthesis Inhibitor,MDA-6
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.7 mg/ml
- Extra Details:
- CDKN1A (p21,CIP1,WAF1),a cyclin-dependent kinase inhibitor,is necessary for proper control of the cell cycle and premature senescence. P21 is a cyclin-dependent kinase (CDK) inhibitor that suppresses proliferation by inhibiting CDK2 and CDK1 activity at the G1/S and G2/M transitions. P21 is a major mediator of p53 to induce cell cycle arrest in G1. p21 can interact with proliferating cell nuclear antigen (PCNA),and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases,which thus leads to a dramatic activation of CDK2,and may be instrumental in the execution of apoptosis following caspase activation. Overexpression of p21 decreases the expression levels of cell cycle progression genes and upregulates senescence-inducing genes.
- Host:
- Rabbit
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse P21
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-p21_polyclonal_antibody-e_ab_70068
