CDK5R1 Polyclonal Antibody
Product Sizes
60 ul
£217.00
E-AB-66296-60UL
120 ul
£317.00
E-AB-66296-120UL
200 ul
£492.00
E-AB-66296-200UL
About this Product
- SKU:
- E-AB-66296
- Additional Names:
- CDK5P35,CDK5R,CDK5R1,NCK5A,p23,p25,p35,p35nck5a
- Application:
- Immunofluorescence
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5), the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
- Host:
- Rabbit
- Immunogen:
- Recombinant fusion protein of human CDK5R1 (NP_003876.1).
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-cdk5r1_polyclonal_antibody-e_ab_66296
