DNAJB14 Polyclonal Antibody
Product Sizes
60 ul
£217.00
E-AB-63811-60UL
120 ul
£317.00
E-AB-63811-120UL
200 ul
£492.00
E-AB-63811-200UL
About this Product
- SKU:
- E-AB-63811
- Additional Names:
- DNAJB14,EGNR9427,PRO34683
- Application:
- Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Acts as a co-chaperone with HSPA8/Hsc70, required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus, the role of these structures, named DJANGOs, is still unclear.
- Host:
- Rabbit
- Immunogen:
- Recombinant fusion protein of human DNAJB14
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-dnajb14_polyclonal_antibody-e_ab_63811
