EIF3C Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-52777-20UL
60 ul
£183.00
E-AB-52777-60UL
120 ul
£272.00
E-AB-52777-120UL
200 ul
£420.00
E-AB-52777-200UL
About this Product
- SKU:
- E-AB-52777
- Additional Names:
- Cell migration inducing protein 17,EIF3C,EIF3CL,EIF3S8,EIF3S8 protein,Eukaryotic translation initiati,Eukaryotic translation initiation factor 3 subunit 8 (110kD),Eukaryotic translation initiation factor 3 subunit 8 110kDa,eIF 3c,eIF3 p110,eIF3-p110,eIF3c
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.6 mg/ml
- Extra Details:
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human EIF3C
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-eif3c_polyclonal_antibody-e_ab_52777
