HLA-DQB1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-52722-20UL
60 ul
£183.00
E-AB-52722-60UL
120 ul
£272.00
E-AB-52722-120UL
200 ul
£420.00
E-AB-52722-200UL
About this Product
- SKU:
- E-AB-52722
- Additional Names:
- DQ beta 1 chain, DQ beta 2 chain,CELIAC1,DQ beta 1 chain,DQB1,HLA DQB,HLA DQB1,HLA class II histocompatibility antigen,HLA-DQB1,HLA-DQB2,IDDM1,Lymphocyte antigen,Major histoc
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.48 mg/ml
- Extra Details:
- HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human HLA-DQB1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-hla_dqb1_polyclonal_antibody-e_ab_52722
