TPMT Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-52714-20UL
60 ul
£183.00
E-AB-52714-60UL
120 ul
£272.00
E-AB-52714-120UL
200 ul
£420.00
E-AB-52714-200UL
About this Product
- SKU:
- E-AB-52714
- Additional Names:
- HGNC:12014,S adenosyl L methionine thiopurine S methyltransferase,TPMT,Thiopurine S methyltransferase,Thiopurine S-methyltransferase,Thiopurine methyltransferase
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1.08 mg/ml
- Extra Details:
- This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human TPMT
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-tpmt_polyclonal_antibody-e_ab_52714
