STX5 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-52597-20UL
60 ul
£183.00
E-AB-52597-60UL
120 ul
£272.00
E-AB-52597-120UL
200 ul
£420.00
E-AB-52597-200UL
About this Product
- SKU:
- E-AB-52597
- Additional Names:
- OTTHUMP00000185028,SED5,STX5,STX5A,Syntaxin 5,Syntaxin 5A,Syntaxin-5,Syntaxin5,Syntaxin5A
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1.14 mg/ml
- Extra Details:
- The membrane protein syntaxin 5 (STX5) is a key component of soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complexes that regulate cellular protein transport, vesicle docking, and membrane fusion. Syntaxin 5 protein is found as a 42 kDa ("long") protein localized to the Golgi complex and endoplasmic reticulum, and a "short" 35 kDa isoform localized primarily to the Golgi. Formation of the syntaxin 5 SNARE complex, which also includes proteins Sec22B, Bet1, GOSR1, GOSR2, and Ykt6, allows for regulation of ER-to-Golgi transport, intra-Golgi transport, and endosome-to-Golgi retrograde transport. Research studies indicate that the syntaxin 5 SNARE complex also plays an essential role in autophagy following autophagosome formation. Intracellular protein transport mediated by the syntaxin 5 complex is required for transport and localized activity of lysosomal proteases. The experimental reduction or deletion of syntaxin 5 complex components results in non-functional lysosomes and accumulation of autophagosomes.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human STX5
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-stx5_polyclonal_antibody-e_ab_52597
