PPM1D Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-52172-20UL
60 ul
£183.00
E-AB-52172-60UL
120 ul
£272.00
E-AB-52172-120UL
200 ul
£420.00
E-AB-52172-200UL
About this Product
- SKU:
- E-AB-52172
- Additional Names:
- EC 3.1.3.16,PP2C delta,PP2C-delta,PP2CD,PPM1D,Ppm1d,Protein phosphata,Protein phosphatase 1D,Protein phosphatase 2C delta isoform,p53 induced protein phosphatase 1,p53-induced protein phosphatase 1,protein phosphatase 1D magnesium-dependent delta isoform
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human PPM1D
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-ppm1d_polyclonal_antibody-e_ab_52172
