KIR2DL5A Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-52098-20UL
60 ul
£183.00
E-AB-52098-60UL
120 ul
£272.00
E-AB-52098-120UL
200 ul
£420.00
E-AB-52098-200UL
About this Product
- SKU:
- E-AB-52098
- Additional Names:
- 5, lo, long cytoplasmic tail, two domains,CD158F,CD158f1,KI2LA,Killer cell immunoglobulin-like receptor 2DL5A,killer cell immunoglobulin-like receptor,killer cell immunoglobulin-like receptor KIR2DL5A
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1.02 mg/ml
- Extra Details:
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human KIR2DL5A
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-kir2dl5a_polyclonal_antibody-e_ab_52098
