DNA-RNA Hybrid Monoclonal Antibody[S9.6]
Product Sizes
25 ul
£134.00
E-AB-48028-25UL
100 ul
£291.00
E-AB-48028-100UL
About this Product
- SKU:
- E-AB-48028
- Additional Names:
- DNA-RNA hybrid,RNA/DNA hybrid
- Application:
- ChIP, Immunofluorescence
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- translate.label.attr.clone:
- S9.6
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. The S9.6 monoclonal antibody recognizes DNA-RNA hybrids (also known as R-loops) and does not bind to single or double stranded DNA. The antibody has high affinity for DNA-RNA hybrids but also binds RNA-RNA hybrids that are AU-rich. The specificity of the antibody appears to be determined by a combination of sequence and structural dependency since R-loop sequence affects binding affinity.
- Host:
- Mouse
- Immunogen:
- F PhiX174 bacteriophage-derived synthetic DNA/RNA
- Isotype:
- IgG2a
- Purification:
- Protein A/G Purification
- Reactivities:
- Wide/Non-species Specific
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:p-dna_rna_hybrid_monoclonal_antibody[s9.6]-e_ab_48028
