NF2 / Merlin Polyclonal Antibody
Product Sizes
25 ul
£134.00
E-AB-40642-25UL
100 ul
£291.00
E-AB-40642-100UL
About this Product
- SKU:
- E-AB-40642
- Additional Names:
- ACN,BANF,Merlin,NF2,Neurofibromin 2,SCH,Schwannomerlin,Schwannomin,neurofibromin 2 (merlin)
- Application:
- Western Blot
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway,a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human NF2 protein expressed by E.coli.
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:_merlin_polyclonal_antibody-e_ab_40642
