GRP78 Polyclonal Antibody
Product Sizes
25 ul
£134.00
E-AB-40588-25UL
100 ul
£291.00
E-AB-40588-100UL
About this Product
- SKU:
- E-AB-40588
- Additional Names:
- GRP-78, HSP70 family protein 5, HSPA5, Heat shock protein family A member 5, Immunoglobulin heavy chain-binding protein,BiP
- Application:
- Western Blot
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- GRP78 (Glucose-regulated protein 78 kDa, also BiP and HSPA5) is a 72 kDa member of the heat shock protein 70 family of proteins. Intracellularly, GRP78 is an endoplasmic reticulum chaperone that participates in protein folding, extracellularly, it induces IL-10 production from T cells and interacts with Cripto to block TGF-beta signaling. Human GRP78 precursor is 654 amino acids (aa) in length. It contains an 18 aa signal sequence and a 636 aa mature region that shows a hydantoinase A region (aa 145-245) and a C-terminal KDEL motif that is present on intracellular GRP78, but absent on secreted GRP78. There is alternative splicing in the signal sequence (aa 1-10), and multiple single aa substitituion. Over aa 1-654, human GRP78 is more than 97% aa identical to mouse and rat GRP78.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human GRP78 protein expressed by E.coli.
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-grp78_polyclonal_antibody-e_ab_40588
