BRCA2 Polyclonal Antibody
Product Sizes
25 ul
£134.00
E-AB-40288-25UL
100 ul
£291.00
E-AB-40288-100UL
About this Product
- SKU:
- E-AB-40288
- Additional Names:
- BRCC 2, BROVCA2, Breast and ovarian cancer susceptibility gene early onset antibody, FACD, FAD 1, FANCB, GLM3,BRCA 2
- Application:
- Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Breast cancer type 2 susceptibility protein
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-brca2_polyclonal_antibody-e_ab_40288
