P53 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-32469-20UL
60 ul
£183.00
E-AB-32469-60UL
120 ul
£272.00
E-AB-32469-120UL
200 ul
£420.00
E-AB-32469-200UL
About this Product
- SKU:
- E-AB-32469
- Additional Names:
- Antigen NY-CO-13,BCC7,Cellular tumor antigen p53,FLJ92943,LFS1,Mutant tumor protein 53,P53,Phosphoprotein p53,TRP53,Tp53,Transformation related protein 53,Tumor protein 53,Tumor protein p53,Tumor suppressor p53,p53,p53 tumor suppressor
- Application:
- IHC-Paraffin, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the C-terminal region of human p53
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-p53_polyclonal_antibody-e_ab_32469
