FAK Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-31399-20UL
60 ul
£183.00
E-AB-31399-60UL
120 ul
£272.00
E-AB-31399-120UL
200 ul
£420.00
E-AB-31399-200UL
About this Product
- SKU:
- E-AB-31399
- Additional Names:
- FADK,FADK 1,FAK related non kinase polypeptide,FAK1,FRNK,Focal adhesion Kinase,Focal adhesion kinase 1,Focal adhesion kinase isoform FAK Del33,Focal adhesion kinase related nonkinase,PPP1R71,Protein phosphatase 1 regulatory subunit 7,p125FAK,pp125FAK
- Application:
- IHC-Paraffin, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human FAK around the non-phosphorylation site of Tyr397.
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-fak_polyclonal_antibody-e_ab_31399
