EGFR Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-31291-20UL
60 ul
£183.00
E-AB-31291-60UL
120 ul
£272.00
E-AB-31291-120UL
200 ul
£420.00
E-AB-31291-200UL
About this Product
- SKU:
- E-AB-31291
- Additional Names:
- Avian erythroblastic leukemia viral (v erb b) oncogene homolog,Cell growth inhibiting protein 40,Cell proliferation inducing protein 61,EGF R,EGFR,Epide,Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog)
- Application:
- IHC-Paraffin, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human EGFR around the non-phosphorylation site of Tyr1016.
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-egfr_polyclonal_antibody-e_ab_31291
