BRCA1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-30669-20UL
60 ul
£183.00
E-AB-30669-60UL
120 ul
£272.00
E-AB-30669-120UL
200 ul
£420.00
E-AB-30669-200UL
About this Product
- SKU:
- E-AB-30669
- Additional Names:
- BRCA 1,BRCA1,BRCA1 DNA repair associated,BRCA1/BRCA2 containing complex subunit 1,BRCA1/BRCA2-containing complex,BRCAI,BRCC 1,BRCC1,Breast Cancer 1,Breast Cancer 1 Early Onset,Breast and ovarian cancer susceptibility protein 1,Breast cance,subunit 1
- Application:
- IHC-Paraffin, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human BRCA1 around the non-phosphorylation site of Ser1423.
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-brca1_polyclonal_antibody-e_ab_30669
