AKT1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-30467-20UL
60 ul
£183.00
E-AB-30467-60UL
120 ul
£272.00
E-AB-30467-120UL
200 ul
£420.00
E-AB-30467-200UL
About this Product
- SKU:
- E-AB-30467
- Additional Names:
- AKT,AKT 1,AKT1,MGC99656,PKB,PKB-ALPHA,PRKBA,Protein Kinase B Alpha,Protein kinase B,Proto-oncogene c-Akt,RAC,RAC Alpha,RAC-PK-alpha,RAC-alpha serine/threonine-protein kinase
- Application:
- IHC-Paraffin, Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Akt1 around the non-phosphorylation site of Thr450.
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-akt1_polyclonal_antibody-e_ab_30467
