Cleaved-NOTCH1 (V1754) Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-30054-20UL
60 ul
£183.00
E-AB-30054-60UL
120 ul
£272.00
E-AB-30054-120UL
200 ul
£420.00
E-AB-30054-200UL
About this Product
- SKU:
- E-AB-30054
- Additional Names:
- NICD,NOTC1,Neurogenic locus Notch homolog protein 1,Notch 1,Notch 1 intracellular domain,Notch homolog 1 translocation associated (Drosophila),TAN1,Translocation-associated notch protein TAN-1,hN1,notch1
- Application:
- IHC-Paraffin, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the Internal region of human Notch 1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-cleaved_notch1_(v1754)_polyclonal_antibody-e_ab_30054
