ERCC1 Monoclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-22036-20UL
60 ul
£183.00
E-AB-22036-60UL
120 ul
£272.00
E-AB-22036-120UL
200 ul
£420.00
E-AB-22036-200UL
About this Product
- SKU:
- E-AB-22036
- Additional Names:
- COFS 4,COFS4,DNA excision repair protein ERCC 1,DNA excision repair protein ERCC-1,DNA excision repair protein ERCC1,ERCC 1,ERCC1,Excision Repair Cross Complementing,Excision repair cross complementation group 1,Excision repair cross complementing 1
- Application:
- Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- translate.label.attr.clone:
- 8K5
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
- Host:
- Mouse
- Immunogen:
- Synthetic Peptide
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:p-ercc1_monoclonal_antibody-e_ab_22036
