Phospho-STAT1 (Tyr701) Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-20981-20UL
60 ul
£183.00
E-AB-20981-60UL
120 ul
£272.00
E-AB-20981-120UL
200 ul
£420.00
E-AB-20981-200UL
About this Product
- SKU:
- E-AB-20981
- Additional Names:
- CANDF7,DKFZp686B04100,IMD31A,IMD31B,IMD31C,ISGF 3,ISGF-3,OTTHUMP00000163552,OTTHUMP00000165046,OTTHUMP00000165047,OTTHUMP00000205845,Signal tr,Signal transducer and activator of transcription 1 91kD,Signal transducer and activator of transcription 1 91kDa
- Application:
- IHC-Paraffin, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Stat1 around the phosphorylation site of Tyr701
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Non-human Primate, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-phospho_stat1_(tyr701)_polyclonal_antibody-e_ab_20981
