Phospho-p70 S6 kinase alpha (Ser447) Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-20959-20UL
60 ul
£183.00
E-AB-20959-60UL
120 ul
£272.00
E-AB-20959-120UL
200 ul
£420.00
E-AB-20959-200UL
About this Product
- SKU:
- E-AB-20959
- Additional Names:
- 70 kDa ribosomal protein S6 kinase 1,KS6B1,P70 S6 Kinase,P70 beta 1,alpha 1,alpha 2,p70 S6 kinase,p70 S6 kinase alpha,p70 S6K,p70 S6K-alpha,p70 S6KA,p70 alpha,p70 ribosomal S6 kinase alpha,p70 ribosomal S6 kinase beta 1,p70(S6,p70(S6K) alpha
- Application:
- IHC-Paraffin, Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human p70 S6 kinase A Alpha around the phosphorylation site of Ser447
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-phospho_p70_s6_kinase_alpha_(ser447)_polyclonal_antibody-e_ab_20959
