Phospho-AKT1 (Thr450) Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-20804-20UL
60 ul
£183.00
E-AB-20804-60UL
120 ul
£272.00
E-AB-20804-120UL
200 ul
£420.00
E-AB-20804-200UL
About this Product
- SKU:
- E-AB-20804
- Additional Names:
- AKT,AKT 1,AKT1,MGC99656,PKB,PKB-ALPHA,PRKBA,Protein Kinase B Alpha,Protein kinase B,Proto-oncogene c-Akt,RAC,RAC Alpha,RAC-PK-alpha,RAC-alpha serine/threonine-protein kinase
- Application:
- IHC-Paraffin, Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Akt1 around the phosphorylation site of Thr450
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-phospho_akt1_(thr450)_polyclonal_antibody-e_ab_20804
