MOB2 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-19976-20UL
60 ul
£183.00
E-AB-19976-60UL
120 ul
£272.00
E-AB-19976-120UL
200 ul
£420.00
E-AB-19976-200UL
About this Product
- SKU:
- E-AB-19976
- Additional Names:
- HCCA2,HCCA2 gene,HCCA2 protein,MOB kinase activator 2,MOB2,MOB2 Mps One Binder homolog,Mob2 homolog,Mps one binder kinase activator like 2,Mps one binder kinase activator-like 2
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1.08 mg/ml
- Extra Details:
- MOB2 (Mps one binder kinase activator-like 2), also known as HCCA2 (Hepatocellular carcinoma-associated gene 2), is a 467 amino acid protein that belongs to the MOB1/phocein family. MOB2 is expressed in lung, spleen, brain, and fetal liver. It is highly expressed in hepatocellular carcinoma. MOB2 is localized in the perinuclear region of the cytoplasm in liver cancer tissues and colocalizes with MAD2L2 in the nucleus of Hela cells. MOB2 is characterized by two N-glycosylation sites, six N-myristolylation sites, two Src homology 3 (SH3), and several phosphorylation motifs which indicate that this protein may play a role in an intracellular signal transduction cascade. MOB2 binds to and regulates the autophosphorylation of the related human serine/threonine kinase 38 (NDR1) and serine/threonine kinase 38L(NDR2). It has been shown that MOB2 plays a critical role in cell cycle regulation. Overexpression of the protein during the G0/G1 phase inhibits cell proliferation causing cell cycle arrest. Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human MOB2
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-mob2_polyclonal_antibody-e_ab_19976
