CCNE1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-19281-20UL
60 ul
£183.00
E-AB-19281-60UL
120 ul
£272.00
E-AB-19281-120UL
200 ul
£420.00
E-AB-19281-200UL
About this Product
- SKU:
- E-AB-19281
- Additional Names:
- CCNE,CCNE1,Ccne1,Cyclin E1,Cyclin Es,Cyclin Et,CyclinE,G1/S specific cyclin E,G1/S-specific cyclin-E1,cyclin E variant ex5del,cyclin E variant ex7del
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.9 mg/ml
- Extra Details:
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human CCNE1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-ccne1_polyclonal_antibody-e_ab_19281
