PSME1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-19193-20UL
60 ul
£183.00
E-AB-19193-60UL
120 ul
£272.00
E-AB-19193-120UL
200 ul
£420.00
E-AB-19193-200UL
About this Product
- SKU:
- E-AB-19193
- Additional Names:
- 11S regulator complex alpha subunit,11S regulator complex subunit alpha,29 kD MCP activator subunit,29kD MCP activator subunit,Activator of multicatalytic protease subunit 1,IFI5111,IGUP I-5111,Interferon gamma IEF SSP 5111,Interferon gamma inducible prot
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.78 mg/ml
- Extra Details:
- The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human PSME1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-psme1_polyclonal_antibody-e_ab_19193
