CBFA2T2 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-19075-20UL
60 ul
£183.00
E-AB-19075-60UL
120 ul
£272.00
E-AB-19075-120UL
200 ul
£420.00
E-AB-19075-200UL
About this Product
- SKU:
- E-AB-19075
- Additional Names:
- alpha subunit 2; runt domain;AML1 MTG8;Core binding factor runt domain alpha subunit 2 translocated to 2;DKFZp313F2116;EHT;ETO homolog on chromosome 20;ETO homologous on chromosome 20;MTG 8 like protein;MTG 8 related protein 1;cbfa2t2;core-binding factor
- Application:
- Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 1.26 mg/ml
- Extra Details:
- In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human CBFA2T2
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-cbfa2t2_polyclonal_antibody-e_ab_19075
