PNRC2 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-18895-20UL
60 ul
£183.00
E-AB-18895-60UL
120 ul
£272.00
E-AB-18895-120UL
200 ul
£420.00
E-AB-18895-200UL
About this Product
- SKU:
- E-AB-18895
- Additional Names:
- 0610011E17Rik,D4Bwg0593e,FLJ20312,MGC11707,MGC93828,MGC99541,OTTMUSP00000010360,OTTMUSP00000010366,PNRC2,Proline rich nuclear receptor coactivator 2,Proline-rich nuclear receptor coactivator 2,RP11-4M23.5,RP23-161N17.3,pnrc2
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.54 mg/ml
- Extra Details:
- Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human PNRC2
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-pnrc2_polyclonal_antibody-e_ab_18895
