IMPA1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-18668-20UL
60 ul
£183.00
E-AB-18668-60UL
120 ul
£272.00
E-AB-18668-120UL
200 ul
£420.00
E-AB-18668-200UL
About this Product
- SKU:
- E-AB-18668
- Additional Names:
- IMP;IMP 1;IMPA;IMPA 1;IMPA1;IMPase;IMPase 1;Inositol 1(or 4) monophosphatase;Inositol monophosphatase;Inositol monophosphatase 1;Inositol(myo) 1(or 4) monophosphatase 1;Inositol-1(or 4)-monophosphatase 1;Lithium sensitive myo inositol monophosphatas
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 0.9 mg/ml
- Extra Details:
- This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human IMPA1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-impa1_polyclonal_antibody-e_ab_18668
