RIPK1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-18284-20UL
60 ul
£183.00
E-AB-18284-60UL
120 ul
£272.00
E-AB-18284-120UL
200 ul
£420.00
E-AB-18284-200UL
About this Product
- SKU:
- E-AB-18284
- Additional Names:
- Cell death protein RIP,FLJ39204,OTTHUMP00000039163,Receptor (TNFRSF) interacting serine threonine kinase 1,Receptor interacting protein,Receptor interacting protein kinase 1,Receptor interacting serine threonine protein kina,receptor interacting protein 1
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.7 mg/ml
- Extra Details:
- Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human RIPK1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-ripk1_polyclonal_antibody-e_ab_18284
