C14orf169 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-17743-20UL
60 ul
£183.00
E-AB-17743-60UL
120 ul
£272.00
E-AB-17743-120UL
200 ul
£420.00
E-AB-17743-200UL
About this Product
- SKU:
- E-AB-17743
- Additional Names:
- 60S ribosomal protein L8 histidine hydroxylase,C14orf169,Chromosome 14 open reading frame 169 ,Histone lysine demethylase NO66,Hypothetical protein FLJ21802,Lysine-specific demethylase NO66,MAPJD,MYC associated protein with JmjC domain,NO66,Nu,hsNO66
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.8 mg/ml
- Extra Details:
- Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human C14orf169
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-c14orf169_polyclonal_antibody-e_ab_17743
