HMGCS1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-16482-20UL
60 ul
£183.00
E-AB-16482-60UL
120 ul
£272.00
E-AB-16482-120UL
200 ul
£420.00
E-AB-16482-200UL
About this Product
- SKU:
- E-AB-16482
- Additional Names:
- 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble),3-hydroxy-3-methylglutaryl coenzyme A synthase,EC 2.3.3.10,HMCS1,HMG CoA synthase,HMG-CoA synthase,HMGCS,HMGCS1,Hydroxymethylglutaryl CoA synthase,Hydroxymethylglutaryl-CoA,cytoplasmic
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.6 mg/ml
- Extra Details:
- HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human HMGCS1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-hmgcs1_polyclonal_antibody-e_ab_16482
