ERN2 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-16413-20UL
60 ul
£183.00
E-AB-16413-60UL
120 ul
£272.00
E-AB-16413-120UL
200 ul
£420.00
E-AB-16413-200UL
About this Product
- SKU:
- E-AB-16413
- Additional Names:
- IRE1-BETA,IRE1b
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1.1 mg/ml
- Extra Details:
- The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1A Alpha and IRE1B Beta are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human ERN2
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-ern2_polyclonal_antibody-e_ab_16413
