DEAF1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-16381-20UL
60 ul
£183.00
E-AB-16381-60UL
120 ul
£272.00
E-AB-16381-120UL
200 ul
£420.00
E-AB-16381-200UL
About this Product
- SKU:
- E-AB-16381
- Additional Names:
- DEAF1,DEAF1 transcription factor,Deaf1,Deformed epidermal autoregulatory factor 1 homolog,NUDR,Nuclear DEA1 related transcriptional regulator,Nuclear DEAF-1-related transcriptional regulator,SPN,Suppressin,Zinc,Zinc finger MYND domain containing protein 5
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 1.4 mg/ml
- Extra Details:
- Suppressin, also known as DEAF1 (deformed epidermal autoregulatory factor 1), SPN, NUDR (nuclear DEAF-1-related transcriptional regulator), or ZMYND5 (zinc finger MYND domain-containing protein 5), is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human DEAF1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-deaf1_polyclonal_antibody-e_ab_16381
