DCC Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-15932-20UL
60 ul
£183.00
E-AB-15932-60UL
120 ul
£272.00
E-AB-15932-120UL
200 ul
£420.00
E-AB-15932-200UL
About this Product
- SKU:
- E-AB-15932
- Additional Names:
- CRC 18,CRC18,CRCR 1,CRCR1,Colorectal cancer related chromosome sequence 18,Colorectal cancer suppressor,DCC,Deleted in colorectal cancer protein,Deleted in colorectal carcinoma,Immunoglobulin superfamily DCC subclass member 1,Netrin receptor DCC,Tumor
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.7 mg/ml
- Extra Details:
- This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human DCC
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-dcc_polyclonal_antibody-e_ab_15932
