SHH Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-15842-20UL
60 ul
£183.00
E-AB-15842-60UL
120 ul
£272.00
E-AB-15842-120UL
200 ul
£420.00
E-AB-15842-200UL
About this Product
- SKU:
- E-AB-15842
- Additional Names:
- HHG 1,HHG-1,HHG1,HLP 3,HLP3,HPE 3,HPE3,Holoprosencephaly 3,MCOPCB5,SHH,SMMC I,SMMCI,Sonic Hedgehog (Drosophila) homolog,Sonic hedgehog homolog,Sonic hedgehog protein,Sonic hedgehog protein C-product,TPT,TPTPS,shh,sonic hedgehog homolog (Drosophila)
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.8 mg/ml
- Extra Details:
- This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human SHH
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-shh_polyclonal_antibody-e_ab_15842
