AVEN Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-15518-20UL
60 ul
£183.00
E-AB-15518-60UL
120 ul
£272.00
E-AB-15518-120UL
200 ul
£420.00
E-AB-15518-200UL
About this Product
- SKU:
- E-AB-15518
- Additional Names:
- 1700013A01Rik;1700056A21Rik;AVEN;Apoptosis caspase activation inhibitor;Cell death regulator Aven;MGC124011;OTTMUSP00000016129;PDCD12;Programmed cell death 12;RP23-52C15.2;mAven L;mAven S
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 0.4 mg/ml
- Extra Details:
- AVEN, a cell death regulator, is an important signal inducer in acute leuke-mias. AVEN is a highly conserved peripheral membrane protein that protects the cell against the proteolytic activation of caspases as well as Apaf-1 mediated apoptosis by interfering with Apaf-1's ability to self-associate. Bcl-2 and Bad also interact with AVEN to prevent apoptosis. AVEN is highly expressed in ovary, heart, thymus, spleen, testis and colon, but can also be detected in other tissues. Erythropoietin and methylprednisolone may play important roles in the expression of AVEN in cardiac tissue, especially after a traumatic brain injury. In young patients suffering from acute lymphoblastic leukemia (ALL), AVEN expression may be a useful tool in prognosis prediction.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human AVEN
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-aven_polyclonal_antibody-e_ab_15518
